Antibody drugs can also be delivered by EVs, as demonstrated in experiments where the encoding genes of antihuman CD3 UCHT1 scFv antibody and antihuman HER2 trastuzumab scFv were transfected into Expi293F cells [171], resulting in SMART-Exos that effectively and selectively induced tumor-specific immunity against HER2-expressing tumors. Here, ERBB2 is linked to neoplasm.