AR and Familial prostate cancer: Some hormonal drugs including estrogens, gonadotropin-releasing hormone analogs, gonadotropin-releasing hormone antagonists, androgen biosynthesis inhibitors, and androgen receptor blockers, which can also achieve lower testosterone, but they have significant side effects and, as the disease progresses, almost all patients will no longer be sensitive to androgens and develop desmoplastic-resistant prostate cancer [4].