Upregulation of CtsB is tightly correlated with the activity of other proteases, which were shown to favor cancer progression, like the urokinase plasminogen activator (uPA)/plasminogen/plasmin [49], matrix metalloproteinase 9 [50] and overexpression of VEGF-C and TGF-β, resulting in angiogenesis promotion [51]. This evidence concerns the gene PLAU and cancer.