ALCAM and asthma: However, since a considerable number of patients are insensitive to cortisone treatment [64,65], and corticosteroids alone typically do not suffice for the management of severe asthma [66,67], there remains a strong need for the development of further drugs targeting other pathways, such as cytokines, cytokine receptors, or cell adhesion molecules such as CD6 or ALCAM [68,69].