BRCA1 and neoplasm: BRCT domains were initially described in the tumour-suppressor protein BRCA1, which featured a pair of tandem BRCT domains extensively studied, and two distinct pockets: one located into the BRCT domain for the interaction with the pSer of the pSer-X-X-Phe peptide motif [29], and another pocket found in the BRCT-BRCT inter region which interacted with the amino acid located at +3 and provided selectivity [19].