In another study, Rao and colleagues show that SIRPα variants-overexpressed cancer cell membrane-wrapped magnetic nanoparticles (gCM-MNs) could effectively polarize M2 macrophages to M1 macrophages by the magnetic nanoparticle cores, facilitating macrophages to phagocytose cancer cells and enhancing anticancer T-cell immunity [177]. The gene discussed is SIRPA; the disease is cancer.