CSF2 and fungal infectious disease: Indeed, various clinical trials have demonstrated that therapies aimed at restoring the innate immune responses of immunocompromised patients, such as the administration of granulocyte colony-stimulating factors (G-CSF), the administration of granulocyte-macrophage colony-stimulating factors (GM-CSF), or granulocyte transfusion to improve neutrophil numbers in neutropenic patients, can prevent or improve outcomes of fungal infection.