Particularly, the groups HC2.5Hi, which provided 2.5 mg/kg Ce6 with a high irradiation dose, and HC5Hi, (Ce6 (5 mg/kg) with a high irradiation dose, showed the best anti-obesity activity through improved leptin, adiponectin, and serum lipid levels in high-fat diet-induced obesity in mice. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.