HDAC1 and melanoma: Figure 5 shows that KAT2A plays a crucial role not only among the eight K-mRNA regulated pathways, but also in the regulation of BETi sensitivity-related proteins and pathways. These proteins and pathways, including BCL2, YAP1, PTEN, HDAC1, the PI3k-Akt-mTOR pathway, and the Hippo pathway [15,51,52,53], were either regulated directly or through MYC by KAT2A (Figure 5b). These results suggest that the inhibition of KAT2A could downregulate BETi resistance-related pathways and further sensitize melanomas to BETis. This contribution could complement those of previous studies [54,55,56,57].