NOS2 and Alzheimer disease: In this study, AD mice treated with PE were more able to combat neuroinflammation by reducing the expression of TNF-α, IL-1β, inducible nitric oxide synthase (iNOS), chemokine C-C motif ligand 2 (CCL2), and IL-10β, when compared to APPsw/Tg2576 mice receiving a standard diet [88], Table 1.