CXCR4 and acute promyelocytic leukemia: In an acute promyelocytic leukemia (APL) model (PML/RARα), green tea treatment reduced blast percentages (CD34 and/or CD117) in the bone marrow and spleen possibly through the induction of apoptosis and reduction in the CXCR4/HIF-1α signaling pathway in response to a decrease in ROS levels [55].