The purple network represented in Figure 5A was built by searching for the genes ROCK1, AKR1B1, JAK2, DHODH, TYK2, PDE4C, TGFBR1, TNKS2, GABRA4, CCND1, PDE4D, OPRD1, RPS6KA1, F13A1, MTNR1B, PDE5A, IGF1R, BRD4, PDE3B, DYRK1A, JAK1, ADORA1, SYK, CSNK1G1, ADORA2B, TNKS, AURKB, EPHB3, CA13, GRK6, and ADORA3, which are the 31 target genes shared by esketamine, arketamine, and depression. The gene discussed is DYRK1A; the disease is major depressive disorder.