The Venn diagram also showed 31 genes intersected by depression, arketamine, and esketamine, 6 genes intersected by depression, suicide, and arketamine (PDE4B, KDM4C, MIF, NOS2, CREBBP, HMOX1), and 6 genes intersected by depression, suicide, and esketamine (SIRT1, PIK3CA, ICAM1, GABRA1, GABRB2, PRF1). The gene discussed is PIK3CA; the disease is major depressive disorder.