AKT1 and cancer: The best analog produced by this work was compound 19 (Figure 8), endowed with an IC50 of 0.038 μM on isolated AKT1 and low micromolar anti-proliferative activity on OVCAR-8, HL60, and HCT-116 cancer cell lines (8.1, 5.3, and 8.9 μM, respectively).