Additionally, derivative 6 induced growth inhibition on different cancer cell lines in the low micromolar range (4.5, 5.7, and 8.7 μM in PC3, HCT116, and U87MG cell lines, respectively) and decreased the levels of pGSK3, pS6, and pFKHR proteins, that are downstream targets of the AKT2 pathway. Here, AKT2 is linked to cancer.