Researchers should keep in mind that several reports indicated a potential toxicity associated with exposure to Perilla frutescens [68,69], and this aspect is particularly important for those patients with severe forms of IgA in whom the estimated glomerular filtration rate is reduced and who need appropriate dose adjustments to avoid progression to end-stage renal disease and need dialysis. The gene discussed is CD79A; the disease is stage 5 chronic kidney disease.