It is a SET and MYND domain-containing protein 2 that methylates histone and non-histone proteins associated with active transcription and is involved in the progression of several malignancies [23], including non-small cell lung carcinoma, colon cancer [24], triple-negative breast cancer [25], hepatocellular malignancy [26], and cervical cancer [27]. The gene discussed is SMYD2; the disease is non-small cell lung carcinoma.