PTGS2 and colorectal carcinoma: The downregulatory potential of 27-desoxy-24, 25-dihydrowithaneferin A, 27-O-glucopyranosylviscosalactone B, withaferin A, withanolide sulfoxide, and withanoside IV has been reported with decreased expression of COX-2 [52,58,59] and Bcl-2 [52] in CRC.