ACHE and early-onset autosomal dominant Alzheimer disease: As earlier discussed, both benzoxazole and oxadiazole moieties are very important for the treatment of Alzheimer’s disease and thus hybrid analogues containing benzoxazole and oxadiazole moieties were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) and molecular docking studies thereafter.