PARP1 and fatty liver disease: They found that long-term ethanol consumption promoted PARP/ART activation, hepatic steatosis, and intense cytokine expression in liver samples, while in vivo pharmacologic inhibition of PARP1/ARTD1 with PJ-34 attenuated triglyceride content and serum alanine transaminase levels in liver, suggesting a milder injury phenotype [63].