Indeed, neutrophilia is one of the hallmarks of COVID-19 immunopathology, which, alongside an over-exuberant pro-inflammatory cytokine storm (CRS), was found in 38% of patients with CXCR1, siglec5, CD177 and the antimicrobial peptide DEFA1 upregulation in severe COVID-19 patients [89,107]. Here, SIGLEC5 is linked to COVID-19.