This individual with the ultra-rapid allele had severe hemolysis, severe anemia and elevated liver and kidney markers, such as BT median 8.8 mg/dL, BD median 5.3 mg/dL, BI median 5.3 mg/dL, SGOT median 99 U/L, SGPT median 154 U/L, LDH median 2044 U/L, glucose mean 144 mg/dL, creatinine median 9.7 mg/dL and urea median 277 mg/dL (Supplementary Table S1). The gene discussed is GOT1; the disease is anemia.