In a modified Delta-24-RGD virus containing the SAPM1 gene encoding human hyaluronidase PH20, Kiyokawa et al. demonstrated decreased levels of HA within the GBM extracellular matrix in orthotopic 005 GBM murine models; consequently, this mediated increased tumor infiltration of CD3, CD8, tumor-associated macrophages, and PD-L1, resulting in prolonged animal survival [40]. The gene discussed is CD274; the disease is glioblastoma.