SAR analysis has demonstrated that alkaloids found in medicinal plants such as Coptis chinensis, Commelina communis, Zingiber officinale, Nigella sativa, Cuminum cyminum, Anemarrhena asphodeloides, and Piper nigrum can improve postprandial hyperglycemia by inhibiting maltase-glucoamylase, which is becoming increasingly important as a target in antidiabetic drug discovery [84,121,137,156,189]. The gene discussed is MGAM; the disease is Hyperglycemia.