TLR4 and serum lipopolysaccharide activity: We did, however, observe that endotoxin AUC0–180min significantly correlated with day 13 (0 min) expression levels of TLR4 (rrm = 0.70; p = 0.003), and fasting serum endotoxin at day 13 was correlated with p65 (rrm = 0.57; p = 0.03), supporting the fact that endotoxemia contributes to host inflammation.