For the individual types of FAS rs6586161 polymorphism, there was a significant association with increased gastric cancer risk for the highest glycemic load and AA type of FAS rs6586161 polymorphism in comparison with the lowest glycemic load and TT type of FAS rs6586161 polymorphism (OR = 5.53, 95% CI = 2.01–15.21). Here, FAS is linked to gastric cancer.