IL6 and Miyoshi myopathy: The deficiency of vitamin D facilitates the advancement of MGUS and SMM to MM by stimulating osteoclasts and enhancing osteoclastogenesis via the generation of various cytokines and molecules that possess the capability of osteoclast-activating factors (OAF) [24], including but not limited to interleukin-6 (IL-6), IL-1β, and IL-3 when interacting with the bone microenvironment [25].