PLOD1 and polycystic ovary syndrome: In a more recent study, Genazzani et al. treated 254 overweight/obese PCOS women with 1 g of MYO and 400 mg of ALA, or with MYO or ALA alone for 12 weeks and showed that LH levels were significantly reduced within the group treated with the combined therapy, whereas this result was not found in patients treated with ALA alone.