At the same time, Iezzi et al. enrolled 26 adolescents affected by PCOS with menstrual irregularities and treated them with 400 mg of inositol and 1000 mg of ALA for six months, obtaining a significant reduction of LH, testosterone, and DHEAS and a significant improvement in estradiol. This evidence concerns the gene SULT2A1 and polycystic ovary syndrome.