Inhibition of 11β-HSD2 by Glyz and its metabolites results in mineralocorticoid excess in renal tissue and increased vascular tone, exasperated contraction to vasopressor hormones and eNOS reduction in the vascular wall [80], and may be the reason as to why reduced vasodilation to Ach was noted in CD AA rings treated with Glyz. This evidence concerns the gene NOS3 and Increased circulating aldosterone concentration.