AD AA rings treated with Glyz showed significantly reduced peptide expression of HMGB-1 in the endothelium (AD vs. AD + Glyz: 8.97 × 10−3 ± 2.39 × 10−3 PI, p < 0.05) (Figure 4E,F,G) and media (AD vs. AD + Glyz: 4.01 × 10−3 ± 1.12 × 10−3, p < 0.0001) (Figure 4F,H). This evidence concerns the gene HMGB1 and Alzheimer disease.