NOS3 and Alzheimer disease: Acute exposure to Hcy had significantly reduced eNOS expression in the endothelium (Hcy vs. AD: 0.36 ± 0.06, p < 0.0001) (Figure 5B,F,H), media (Hcy vs. AD: 0.46 ± 0.13 PI, p < 0.001) (Figure 5B,F,I) and adventitia (Hcy vs. AD, p < 0.0001) (Figure 5B,F,J) when compared to rabbits fed a 4-week AD to initiate the development of HHcy-induced atherogenesis.