Moreover, no difference in eNOS expression was observed in the endothelium and media of AD and AD + Glyz treated rings (Figure 5G–I); however, AD + Glyz treated rings had reduced eNOS expression in the adventitia (AD: 0.92 ± 0.07 vs. AD + Glyz: 0.18 ± 0.06, p < 0.0001) (Figure 5F,J). Here, NOS3 is linked to Alzheimer disease.