TNF and atherosclerosis: Similar results have been reproduced in diabetic rats with atherosclerosis (induced by high fat diet and low dose streptozotocin), as a 16-week treatment of Glyz was able to significantly reduce serum and aorta levels of TNFα and other pro-inflammatory cytokines (i.e., interleukin-1β and -6) as well as decreased atherosclerotic plaque lesion size and intima thickness [72].