Among the blood indicators, the observed negative association between fish oil supplementation and CHD incidence was mainly mediated by CRP, HDL-C, and IGF-1 in individuals with prediabetes, while HbA1c, VLDL-C, HDL-C, and ApoA primarily mediated the association in patients with diabetes (all p < 0.05). The gene discussed is IGF1; the disease is coronary artery disorder.