This aim can be achieved in peritoneal dialysis patients through different strategies: the use of renin–angiotensin–aldosterone system blockers, adequate control of blood pressure in order to prevent hypertension as well as hypotensive episodes, cautious prescription of diuretics, adoption of incremental peritoneal dialysis modality with careful monitoring of blood tests and clinical conditions, and use of icodextrin solution [29]. The gene discussed is REN; the disease is hypertensive disorder.