Regarding colon tumors induced by HT29 in mice, a study by Sem et al. (2019) [198] revealed lower tumor growth and a decrease in blood vessels (inhibition of angiogenesis), levels of expression of the CD-31 protein (responsible for vascularization), and Ki-67 (cell proliferation marker) after treatment with liposomes loaded with the flavonoid apigenin. The gene discussed is MKI67; the disease is neoplasm.