The results of this study showed that administration of 400 mg/kg of polysaccharides extract inhibited BACE1 and Aβ deposition in over 50%, as well as causing a significant inhibition of APP, AChE, and p-tau protein in AlCl3- and D-galactose-induced AD Wistar rats, in which aluminum works as a neurotoxic and D-galactose as a senescence stimulating agent, inducing AD-like symptoms. The gene discussed is MAPT; the disease is Alzheimer disease.