In the context of prostate cancer treatment, Sun’s silicic acid-bound CD/CSF-1R siRNA supermolecule nanoparticles can target the siglec-1 (CD169) overexpressed by M2 macrophages [33] to obtain the up-regulated CSF-1/CSF-1R signaling pathway [34], which is related to poor prognosis of cancer patients [35] (Figure 3). The gene discussed is CSF1R; the disease is prostate cancer.