MMP14 and cancer: The presence of MMP-14 has been linked to unfavorable outcomes in patients suffering from a variety of cancers [212], including melanoma [213]; advanced neuroblastoma [214]; mesothelioma [215]; lung cancer [216]; tongue, head, and neck carcinoma [217,218]; and bladder [219], breast [220], ovarian [221], pancreatic [222] and colorectal cancers [71,223].