AKT1 and cancer: Several molecular pathways are involved in cancer growth and metastasis; PI3K/AKT pathway activation has been recorded to improve tumorigenesis, metastasis, the epithelium–mesenchymal transition, and the drug resistance of cancer cells [16] via upregulating the expression of c-MYC, which increases the growth, differentiation, invasion, and chemotherapy drug resistance of cancer cells [17].