Arthritis, an inflammatory joint disease, occurs through dysregulation of pro-inflammatory cytokines such as IL1β and TNFα, pro-inflammatory enzymes such as cyclooxygenase 2 (Cox-2) and lipoxygenase, expression of adhesion molecules and MMPs, and proliferation of synovial fibroblasts (SFBs) [45]. Here, PTGS2 is linked to arthritic joint disease.