In 115 patients with rheumatoid arthritis (RA), 20 with osteoarthritis (OA), 28 with psoriasis arthritis, 24 with ankylosing spondylitis, 3 groups with systemic autoimmune diseases, and 30 healthy controls were examined; MMP1 levels were elevated in RA, OA, psoriasis arthritis, systemic lupus erythematosus, and mixed connective tissue disease [14]. This evidence concerns the gene MMP1 and osteoarthritis.