Analysis of inflammation-related proteins in the serum collected from IBD patients revealed a significant increase in 21 proteins including IL6 and MMP10 in the serum and a significant decrease in 4 proteins compared to the control sample. IL6 and MMP10 were also significantly increased in saliva of these patients and correlated with their expressions in the serum. These findings suggest that the oral cavity reflects ongoing intestinal inflammation, and that saliva can be used as a non-invasive source of IBD biomarkers. The gene discussed is IL6; the disease is inflammatory bowel disease.