CASP3 and neoplasm: As shown in Figure 5b, after permeating the membrane of apoptotic tumor cell, C-SNAF underwent L-DEVD cleavage via activated caspase-3 and disulfide reduction to trigger intramolecular cyclization to form the macrocycle C-SNAF-cycl, which further proceeded the in situ aggregation to yield nanoaggregates.