BRAF and cancer: The RAS-RAF-MEK-ERK cascade, crucial for various cellular processes such as regulation of cell cycle (including apoptosis), cell differentiation and proliferation [88], involving all the members of this kinase family, but, among them, B-Raf (expressed by the chromosome 7 located oncogene BRAF) [89] is the PK frequently altered in multiple cancer types, with notable mutation rates observed in skin, thyroid, gastrointestinal (GI), and lung cancers [90].