Univariate COX regression analysis indicated that the risk of all-cause mortality in HF patients was increased with age > 65 (HR = 1.978, 95% CI = 1.056–3.704, p = 0.033), serum creatinine > 2 mg/dL (HR = 7.687, 95% CI = 3.191–18.518, p < 0.01), NT-pro-BNP > 4000 pg/mL (HR = 3.184, 95% CI = 1.705–5.947, p < 0.01) and left atrial diameter > 55 mm (HR = 2.847, 95% CI = 1.482–5.467, p < 0.01). The gene discussed is NPPB; the disease is hydrops fetalis.