EGFR and neoplasm: The researchers came to a conclusion that such an administration of cholecalciferol can render ALA-PDT to be a safe neo-adjuvant and it could be used for cancer pretreatment before PDT for human patients [283] Bhuvaneswari et al. evaluated the efficacy of PDT in combination with an epidermal growth factor receptor (EGFR) inhibitor, nimotuzumab, in oral cancer cell lines and an OSCC xenograft tumor model.