The average tumor volumes in the mice treated with rPRV-gG−-TK−-gEgI−, rPRV-IL-18-γ, rPRV-PH20 and rPRV-IL-18-γ-PH20 were 1415.10 mm3, 1183.94 mm3, 1226.56 mm3 and 885.66 mm3, respectively. This evidence concerns the gene SPAM1 and neoplasm.