In contrast, tumor cells infected with rPRV-gG−-TK−-gEgI−, rPRV-IL-18-γ, rPRV-PH20 and rPRV-IL-18-γ-PH20 displayed varying degrees of lysis, manifested by morphological features such as rounding and rupturing. The gene discussed is SPAM1; the disease is neoplasm.