IL1B and Sepsis: The other genes that are more frequent in sepsis all encode for toxins or enzymes that activate parts of the immune response: cnf1 activates the NLP3 inflammasome (via Rho GTPase activation), resulting in IL1b production [22]; vat is a member of Serine protease autotransporter proteins (SPATE) and induces vacuole-forming in bladder epithelium and loss of intercellular contacts.