Accumulation of ligands for the C-C chemokine receptor and receptors that act as signals for the migration of CD8+ T cells and NK cells showed that L. casei ATCC 393 induced strong Th1 immune responses and impaired tumor growth for the production of immunostimulatory cytokines in lymphatic organs and secretion of molecules that induced the migration of cytotoxic T cells in the tumor. This evidence concerns the gene CD8A and neoplasm.