Administration of lactobacilli has been shown to stimulate the production of cytotoxic cells, maturation of Th1 helper T cells, and their cytokine production with activation signaling pathways inducing the differentiation, development, and targeted intra-tumor migration of immune cell populations CD8+ T and NK that increased cancer cell apoptosis through cell interactions and secretion of anti-cancer factors [27]. Here, CD8A is linked to cancer.