For example, the E. coli strain of O111:H2 serotype, carrying the Shiga toxin 2 (stx2) gene and showing aggregative adhesion (AA) to HEp-2 cells, caused the outbreak of hemorrhagic colitis (HC) and hemolytic–uremic syndrome (HUS) in France in 1992 and was estimated to be a hetero-pathogenic enteroaggregative hemorrhagic E. coli (EAHEC) strain [5]. Here, STX2 is linked to hemolytic-uremic syndrome.