The current findings are consistent with previous research that has used integrin receptors as specific targets to assist with the therapeutic action of other bioactive chemicals, such as IR780 NIR dye encapsulated in lipid nanoparticles for HEK29(3)-vRFP cells [38], anti-STAT3 siRNA for B16F10 melanoma cells using cationic liposomes [39], and DSPE-PEG micelles to encapsulate indocyanine-green-targeting SGC7901 gastric cancer cells [40] among others. Here, STAT3 is linked to melanoma.