Additionally, succinated and inactivated Kelch-Like ECH-Associated Protein 1 (KEAP1) cannot interact and cannot promote the proteasomal degradation of the transcription factor nuclear factor Erythroid 2 Like 2 (NRF2), which induces antioxidant response mitigating oxidative stress in tumor cells, thus promoting cell survival (Figure 2) [23,24]. This evidence concerns the gene KEAP1 and neoplasm.