Also, green tea, with its main constituents, catechins, possesses anti-obesity action by increasing energy expenditure and fat oxidation and downregulating hepatic enzymes that are involved in lipid metabolism [15] It also upregulates adiponectin levels by inhibiting ERK; increases the phosphorylation of PPAR-γ; and, consequently, increases its expression [16]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.