SERPINA12 and obesity due to melanocortin 4 receptor deficiency: The adipocytokine vaspin, which increases with obesity, was significantly reduced in the adipose tissue of the treated rat groups (conventional and nano-formulated (100 mg/kg); conventional and nano-formulated (300 mg/kg)), as well as orlistat group when compared with the HFD group (p < 0.0001 in all groups).