SMO and cancer: A similar activity was observed with the metabolite tumidulin, isolated from the species Niebla sp., where, in the study, it was reported that both metabolite and extract reduced the spheroid formation of CSC221 and colorectal cancer cell lines, in addition to modulating the expression of genes associated with Hedgehog signaling pathways, such as the smoothened proteins (SMO) and the ones from the Gli family; thus, reducing the stemness potential of the cancer cell lines [36].