NF-kB signaling also plays a critical role in promoting CLL cell viability [82], and an in-vitro study determined that the statin, simvastatin, induces apoptosis of CLL cells by lowering the BCL-2/Bax ratio and through activation of caspase 9 [69]. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.