The major KEGG pathways with the most prominent connections to the target genes and CLAE molecules were pathways in cancer (degree = 9), proteoglycans in cancer (degree = 7), IL-17 signaling pathway (degree = 6) and coronavirus disease, lipid and atherosclerosis, TNF signaling pathway and AGE-RAGE signaling pathway in diabetic complications (degree = 5). This evidence concerns the gene RENBP and atherosclerosis.