Mutations in the IMPDH1 gene cause autosomal dominant retinal degeneration, namely retinitis pigmentosa type 10 (RP10) or Leber congenital amauriosis type 11 [116,117,118,119,120], while mutations in the IMPDH2 gene have been only recently discovered and lead to severe juvenile neuropathies [121,122]. The gene discussed is IMPDH1; the disease is retinitis pigmentosa 10.